PVi provides a continuous noninvasive measure of the relative variability in the photoplethysmograph (pleth) during respiratory cycles that may be used as a dynamic indicator of fluid responsiveness in select populations of mechanically ventilated adult patients.1
PVi is available alongside Masimo SET® Pulse Oximetry and rainbow® Pulse CO-Oximetry.
Pleth Variability Index (PVi) is dynamic index between 0-100 which measures the relatve variability of the pleth waveform noninvasively detected from a pulse oximetry sensor. It uses the detected pleth amplitudes to automatically calculate the dynamic changes that occur during the respiratory cycle. Higher variability in the pleth waveform has been associated with preload dependence and fluid responders.
This allows PVi to be used as a noninvasive dynamic indicator of fluid responsiveness in select populations of mechanically ventilated adult patients.
The ability of PVi to predict fluid responsiveness can be variable and influenced by numerous patient, procedural, and device-related factors. Fluid management decisions should be based on a complete assessment of the patient’s conditon and not solely on PVi.
In a study of eighty-two patients undergoing major abdominal surgery, researchers found that PVi-based goal-directed fluid management reduced the volume of intraoperative fluid infused and reduced intraoperative and postoperative lactate levels.4
In another study of one hundred and nine patients undergoing colorectal surgery, researchers found that the implementation of an enhanced recovery protocol which included PVi led to improved patient satisfaction and substantial reductions in lengths of stay, complication rates, and costs for patients.5
The GDT and ERAS studies summarized above were conducted on patients undergoing a specific type of procedure and following a specific fluid management protocol. The results may not be reflective of all cases and the described GDT and ERAS protocols may not be appropriate for all types of patients and procedures.
SpHb is a noninvasive continuous parameter for monitoring total hemoglobin and is provided alongside PVi on rainbow® Pulse CO-Oximetry sensors. The following hepatic surgery case depicts the effect of dilution on total hemoglobin upon the infusion of 2.5L of crystalloid.6
Kaplan–Meier estimates of survival when including the severity of surgery
A single-center quality initiative involving 18,716 patients in the OR, ICU, and PACU was implemented in Limoges, France. The study used a GDT protocol with PVi in conjunction with a blood transfusion protocol based on SpHb. Results demonstrated that monitoring with SpHb and PVi integrated in a vascular filling algorithm was associated with earlier transfusion and reduced 30- and 90-day mortality by 33% and 29%, respectively, on a whole hospital scale.7
Cannesson et al. Journal of Cardiothoracic Vas Anes. 2010.
Bellamy MC. Br J Anaesth. 2006 Dec;97(6):755-7.
Chandler et al. J Clin Monit Comput. 2012.
Forget P et al. Anesth Analg. 2010 Oct;111(4):910-4.
Thiele RH et al. J Am Coll Surg. 2015 Apr;220(4):430-43.
Perel Critical Care (2017) 21:291
Cros et al. J Clin Monit Comput. Aug 2019: 1-9.
SpHb is not intended to replace laboratory blood testing. Clinical decisions regarding red blood cell transfusions should be based on the clinician’s judgment considering among other factors: patient condition, continuous SpHb monitoring, and laboratory diagnostic tests using blood samples.
Caution: Federal (USA) law restricts this device to sale by or on the order of a physician. See instructions for use for full prescribing information, including indications, contraindications, warnings, and precautions.
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