PVI®Pleth Variability Index
Pleth Variability Index (PVI®) is a breakthrough measurement that may help clinicians noninvasively and continuously assess fluid status of patients.
- > Fluid administration is critical
- • To increase cardiac output and optimize patient status, enabling end organ preservation1
- > Unnecessary fluid administration associated with increased morbidity and mortality2
- • Fluid administration causes hemodilution, which reduces Hb concentration and increases likelihood of transfusion3
- > Traditional static measurements not reliable to predict volume responsiveness
- • CVP, SBP, DBP, Pulse Pressure, Wedge Pressure, Cardiac output4
- > New dynamic monitoring technologies are effective
- • Proven to improve outcomes but are invasive or complex - and costly5
- • Examples: Pulse pressure variation, stroke volume variation
- • Appropriate for higher-risk patients
- > There is a large opportunity to improve care in moderate to low risk population
- • Using low cost, noninvasive technology
- > PVI has been shown to help clinicians:
- • Predict fluid responsiveness in mechanically ventilated patients under general anesthesia during surgery and in the ICU in adults6,7 and children8
- • Improve fluid management and decrease lactate levels compared to standard care9
"PVI demonstrated high accuracy in discriminating fluid responders from non-responders—providing a unique opportunity to better manage a patient's fluid volume to optimize cardiac performance and organ perfusion."
Maxime Cannesson, MD
Associate Professor of Anesthesiology
in the Department of Anesthesiology &
Perioperative Care at the University of California, Irvine
Dr. Maxime Cannesson on the clinical value of PVI
Masimo rainbow® is a noninvasive monitoring platform enabling the assessment of multiple blood constituents and physiologic parameters that previously required invasive or complicated procedures, in addition to providing Masimo SET® Measure-through Motion and Low Perfusion™ pulse oximetry.
- > Total Hemoglobin (SpHb®)
- > Carboxyhemoglobin (SpCO®)
- > Methemoglobin (SpMet®)
- > Oxygen Content (SpOC™)
- > Acoustic Respiration Rate (RRa™)
- > Oxygen Saturation (SpO2)
- > Pulse Rate (PR)
- > Perfusion Index (PI)
- > Pleth Variability Index (PVI®)
The upgradeable rainbow® platform lets you choose the rainbow® measurements that are right for you now and be confident that your investment in patient safety won’t become obsolete tomorrow.
Pleth Variability Index
Pleth Variability Index
- 1 Perel A. Anesth Analg. 2008; 106 (4):1031-33
- 2 Bundgaard-Nielsen M et al. Acta Anaesthesiol Scand. 2007; 51(3):331-40
- 3 Huybregts RA et al. Anesth Analg. 2009. 109(2): 331-339.
- 4 Michard F et al. Chest. 2002; 121(6):2000-08
- 5 Joshi G et al. Anesth Analg. 2005; 101:601-5.
- 6 Cannesson M. et al. Br J Anaesth. 2008;101(2):200-6.
- 7 Loupec T. et al. Crit Care Med. 2011;39(2):294-299.
- 8 Byon H et al. BJA 2012 December; DOI 10.1093/bja/aes467
- 9 Forget P. et al. Anesth Analg. 2010;111(4):910-4.