Clinical Evidence - SedLine® Brain Function Monitoring

Featured Clinical Studies:

Titration of Delivery and Recovery from Propofol, Alfentanil, and Nitrous Oxide Anesthesia.
Drover D.R., Lemmens H.J., Pierce E.T., Plourde G., Loyd G., Ornstein E., Prichep L.S., Chabot R.J., Gugino L. Anesthesiology 2002; 97:82–9.
 
Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence.
Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL. Anesthesiology. 2014 Nov;121(5):990-8. doi:10.1097/ALN.0000000000000436.
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Prospective Comparison of Patient State Index (PSI) Between Propofol Sedation and Intravenous Conscious Sedation During Colonoscopy
Goudra B., Singh P., Samuel A., Cifuentes E. American Society of Anesthesiologists 2014; A3158.
   
Sedation Spectrum in Patients Undergoing Advanced Gastrointestinal (GI) Endoscopic Procedures With Propofol
Goudra B., Singh P., Augustus S. American Society of Anesthesiologists 2014; A1230.
   
Is The Patient State Analyzer With The Psarray2 A Cost-Effective Alternative To The Bispectral Index Monitor During The Perioperative Period?
White P.F., Tang J., Ma H., Wender R.H., Sloninsky A., Kariger R. Anesth Analg. 2004 Nov;99(5):1429-35.
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A Comparison Of Patient State Index And Bispectral Index Values During The Perioperative Period.
Chen X., Tang J., White P.F., Wender R.H., Ma H., Sloninsky A., Kariger R. Anesth Analg. 2002 Dec;95(6):1669-74.
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Advanced Monitoring Is Associated with Fewer Alarm Events During Planned Moderate Procedure-Related Sedation: A 2-Part Pilot Trial.
Applegate RL 2nd, Lenart J, Malkin M, Meineke MN, Qoshlli S, Neumann M, Jacobson JP, Kruger A, Ching J, Hassanian M, Um M. Anesth Analg. 2016 Feb 1.
 

Full Citation List of All Available Studies:*

Advanced Monitoring Is Associated with Fewer Alarm Events During Planned Moderate Procedure-Related Sedation: A 2-Part Pilot Trial.
Applegate RL 2nd, Lenart J, Malkin M, Meineke MN, Qoshlli S, Neumann M, Jacobson JP, Kruger A, Ching J, Hassanian M, Um M. Anesth Analg. 2016 Feb 1.
 
Propofol and non-propofol based sedation for outpatient colonoscopy-prospective comparison of depth of sedation using an EEG based SEDLine monitor.
Goudra B, Singh PM, Gouda G, Borle A, Carlin A, Yadwad A. J Clin Monit Comput. 2015 Sep 12. [Epub ahead of print] PubMed PMID: 26364193.
 
The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia.
Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN. Br J Anaesth. 2015 Jul;115 Suppl 1:i46-i57. doi: 10.1093/bja/aev213. PMID: 26174300 [PubMed - in process]
 
Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence.
Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL. Anesthesiology. 2014 Nov;121(5):990-8. doi:10.1097/ALN.0000000000000436.
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Prospective Comparison of Patient State Index (PSI) Between Propofol Sedation and Intravenous Conscious Sedation During Colonoscopy
Goudra B., Singh P., Samuel A., Cifuentes E. American Society of Anesthesiologists 2014; A3158.
   
Sedation Spectrum in Patients Undergoing Advanced Gastrointestinal (GI) Endoscopic Procedures With Propofol
Goudra B., Singh P., Augustus S. American Society of Anesthesiologists 2014; A1230.
   
A Randomized Controlled Trial of Probability Ramp Control of Propofol for Esophagogastroduodenoscopy
Mandel J.E., Sarraf E. 2014 STA Annual Meeting, January 15-18, Orlando, FL.
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Depth of Sedation Does Not Predict Episodes of Apnea
Drover D.R., Tanaka P. Annual Meeting of the International Anesthesia Research Society. San Diego, CA. May 4-7.
abstract  
Incidence of Deep Sedation and Respiratory Compromise During Procedural Sedation
Applegate R., Macknet M., Qoshlli S., Mehdizadeh A., Jacobson P., Neumann M., Allard M. 2013 Annual Meeting of the International Anesthesia Research Society. San Diego, CA. May 4-7.
abstract  
Sleep Disruption in the Intensive Care Unit.
Vacas S., McInrue E., Maze M., Leung J. Proceedings of the American Society of Anesthesiologists, October 13, 2012. Washington DC: A396
abstract  
Sedation in Adults Receiving Mechanical Ventilation: Physiological and Comfort Outcomes.
Grap M.J., Munro C.L., Wetzel P.A., Best A.M., Ketchum J.M., Hamilton V.A., Arief N.Y., Pickler R., Sessler C.N. Am J Crit Care. 2012 May;21(3):e53-e64.
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Evaluation of the Sedline to Improve the Safety and Efficiency of Conscious Sedation.
Caputo T.D., Ramsay M.A., Rossmann J.A., Beach M.M., Griffiths G.R., Meyrat B., Barnes J.B., Kerns D.G., Crump B., Bookatz B., Ezzo P. Proc (Bayl Univ Med Cent). 2011 Jul;24(3):200-4.
 
Incidence of Postoperative Cognitive Dysfunction Following Desflurane or Sevoflurane General Anesthesia in Elderly Patients: a Randomized Controlled Trial.
Nguyen M., Kim A., Applegate R., Rasmussen T., Anderson D., Azer S., Allard M. Proceedings of the 2011 Annual Meeting of the American Society of Anesthesiologists. A614.
 
Prospective Comparison of Global Electroencephalogram to Frontal Sedline Electroencephalogram Monitoring for the Evaluation of Intraoperative Burst Suppression During Elective Intracranial Surgery.
Nasseri-Noori K.A., McIvor D., Hsu F., Olson M., Allard M., Losey T., Macknet M., Applegate R. Proceedings of the 2011 Annual Meeting of the American Society of Anesthesiologists. A499.
 
Titration of Sevoflurane in Elderly Patients: Blinded, Randomized Clinical Trial, in Non-Cardiac Surgery after Beta-Adrenergic Blockade.
Drover D.R., Schmiesing C., Buchin A.F., Ortega H.R., Tanner J.W., Atkins J.H., Macario A. J Clin Monit Comput. 2011 Jun;25(3):175-81.
 
Surges of Electroencephalogram Activity at The Time Of Death: A Case Series.
Chawla L.S., Akst S., Junker C., Jacobs B., Seneff M.G. J Palliat Med. 2009 Dec;12(12):1095-100.
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Processed Quantitative EEG Monitoring Reduces Postoperative Nausea and Vomiting in Nonsmoking Patients Undergoing Laparoscopic Tubal Ligation.
Cassingham S.F., Khan M., Alaniz P., Munsterman L., Smith C., Kaji S. Proceeding of the 2006 Annual Meeting of the International Anesthesia Research Society: S-163.
 
Facilitating Perioperative Beta Blockade: Titration of Anesthetic to Processed Electroencephalogram Parameters.
Thong A.E., Gaupp A., Ellis J.E. Proceeding of the 2006 Annual Meeting of the International Anesthesia Research Society: S-65.
 
Patient State Index.
Drover D., Ortega H.R. Best Pract Res Clin Anaesthesiol. 2006 Mar;20(1):121-8.
 
Comparison of Depth of Sedation Measured by PSA 4000 and Richmond Agitation-Sedation Scale (RASS).
Sessler C.N., Kollef M., Hamilton A., Grap M.J., Jefferson D. CHEST 2005; 128.
 
Patient State Index During A Cardiac Arrest In The Operating Room.
Nguyen N.K., Lenkovsky F., Joshi G.P. Anesth Analg. 2005 Jan;100(1):155-7.
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Is The Patient State Analyzer With The Psarray2 A Cost-Effective Alternative To The Bispectral Index Monitor During The Perioperative Period?
White P.F., Tang J., Ma H., Wender R.H., Sloninsky A., Kariger R. Anesth Analg. 2004 Nov;99(5):1429-35.
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A Comparison of Patient State Index (PSI) Changes and Remifentanil Requirements during Cardiopulmonary Bypass in Infants Undergoing General Anesthesia with or without Spinal Anesthesia.
Drover D., Hammer G.B., Williams G., Boltz M., Ramamoorthy C. Anesthesiology 2004; 101: A1453.
 
The Response of the Patient State Index (PSI) to Different Anesthetic Types.
Drover D., Plourde G., Loyd G., Ortega H.R., Frazer D. Anesthesiology 2004; 101: A339.
 
Validation of the EEG Electrode Placement for the Patient State Index (PSI).
Drover D., Plourde G., Loyd G., Ortega H.R., Frazer D. Anesthesiology 2004; 101: A322.
 
The Patient State Index Correlates Well with the Ramsay Sedation Score in ICU Patients.
Ramsay M.A., Huddleston P., Hamman B., Tai S., Greg M. Anesthesiology 2004; 101: A338.
 
The Patient State Index Is an Indicator of Inadequate Pain Management in the Unresponsive ICU Patient.
Ramsay M.A., Huddleston P., Henry C., Marcel R., Tai S. Anesthesiology 2004; 101: A349.
 
Nurse-Administered Propofol Sedation (NAPS) for Gastrointestinal Endoscopic Procedures: NAPS or NAPA?
Ramsay M.A., M Hein T. Anesthesiology 2004; 101: A68.
 
Is Patient State Index of EEG Better Than Bispectral Index of EEG in Assessing Different Levels of Sedation as Judged by Ramsey Sedation Score in ICU Patients?
Shah N., Quijano A. Anesthesiology 2004; 101: A293.
 
The Impact of Addition of N2O on BIS, PSI, and Entropy during a Stable Sevoflurane Anesthetic.
Soto R.G., Smith R.A., Miguel R.V. Anesthesiology 2004; 101: A334.
 
Sedation after Spinal Anesthesia in Elderly Patients: A Preliminary Observational Study with the PSA-4000.
Kurup V., Ramani R., Atanassoff P.G. Can J Anaesth. 2004 Jun-Jul;51(6):562-5.
 
Assessment of Patient State Index (PSI) and Bispectral Index (BIS) Values during the Recovery Period after Outpatient Surgery.
Tang J., White P. F., Wender R. H. Proceeding of the 2004 Annual Meeting of the International Anesthesia Research Society: S-125.
 
Comparative Evaluation of Electroencephalographic Patient State Index (PSI) and Bispectral Index (BSI) Values during Ambulatory Anesthesia.
Tang J., White P. F., Wender R. H. Proceeding of the 2004 Annual Meeting of the International Anesthesia Research Society: S-9.
 
Comparison of Patient State Index (PSI) and Bispectral Index (BSI) Response to Propofol and Desflurane during Ambulatory Surgery.
Tang J., White P. F., Wender R. H. Proceeding of the 2004 Annual Meeting of the International Anesthesia Research Society: S-124.
 
The Patient State Index as an Indicator of the Level of Hypnosis under General Anaesthesia.
Prichep L.S., Gugino L.D., John E.R., Chabot R.J., Howard B., Merkin H., Tom M.L., Wolter S., Rausch L., Kox W.J. Br J Anaesth. 2004 Mar;92(3):393-9.
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Patient State Index (PSI) Measures Depth of Sedation in Intensive Care Patients.
Schneider G., Heglmeier S., Schneider J., Tempel G., Kochs E.F. Intensive Care Med. 2004 Feb;30(2):213-6.
 
EEG-Based Indices of Anaesthesia: Correlation between Bispectral Index and Patient State Index?
Schneider G., Mappes A., Neissendorfer T., Schabacker M., Kuppe H., Kochs E. Eur J Anaesthesiol. 2004 Jan;21(1):6-12.
 
The Impact of Addition of N2O on BIS and PSI during a Stable Sevoflurane Anesthetic.
Soto R.G., Fu E.S., Creighton D.D. Anesthesiology 2003; 99: A319.
 
Detection of Awareness in Surgical Patients with EEG-Based Indices - Bispectral Index and Patient State Index.
Schneider G., Gelb A.W., Schmeller B., Tschakert R., Kochs E. Br J Anaesth. 2003 Sep;91(3):329-35.
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A Comparison Of Patient State Index And Bispectral Index Values During The Perioperative Period.
Chen X., Tang J., White P.F., Wender R.H., Ma H., Sloninsky A., Kariger R. Anesth Analg. 2002 Dec;95(6):1669-74.
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Titration of Delivery and Recovery from Propofol, Alfentanil, and Nitrous Oxide Anesthesia.
Drover D.R., Lemmens H.J., Pierce E.T., Plourde G., Loyd G., Ornstein E., Prichep L.S., Chabot R.J., Gugino L. Anesthesiology 2002; 97:82–9.
 
The Physiometrix PSA 4000 Decreases Propofol Usage and Hastens Discharge in Gynecological Day Surgery Procedures.
Cassingham S.F., Hebert T., Lemaire R., Cook R., McPherson P.K. Anesthesiology 2002; 96: A5.
 
Physiometrix PSA 4000 Processed EEG Monitoring Augments the Anesthesia Sparing Effect of Dexmedetomidine.
Cassingham S.F., Hebert T., Cook R., Biggs R., McPherson P.K. Anesthesiology 2002; 96: A546.
 
Can the Patient State Index (PSI) Be Used a Measure of Sedation on the Intensive Care Unit (ICU)?
Schneider G., Heglmeier S., Schneider J., Kochs, E. Anesthesiology 2002; 96: A298.
 
Detection of Awareness during Anesthesia: Bispectral Index (BIS) or Patient State Index (PSI)?
Schneider G., Grineisen Y., Heindl B.K., Kochs E.F. Anesthesiology 2002; 96: A312.
 
Comparison of PSA and BIS Monitoring during General Anesthesia with Propofol and Desflurane.
Tang J., Chen X., White P.F., Wender R., Naruse R. Proceeding of the 2002 Annual Meeting of the International Anesthesia Research Society: S-21.
 
Women Patients Require More Propofol for General Anesthesia than Men.
Prichep L. Drover D., Anesthesiology 2001; 95:A481.
 
QEEG Changes Correlate with Quality of Emergence from General Anesthesia.
Gugino L., Chabot R., Aglio L., Block-Salisbury E., Prichep L., John E.R. Anesthesiology 2001; 95:A288.
 
Patient State Index Assesses Arousal Level.
Gugino, L., Chabot, R., Aglio, L., Prichep, L., Formanek, V. Anesthesiology 2001; 95:A282.
 
Comparison of Bispectral Index and Patient State Index during Induction of Anesthesia for Open Heart Surgery.
Mappes A., Gruendel A., Kuppe H. Anesthesiology 2001; 95:A279.
 
Patient State Index (PSI): Optimization of Delivery and Recovery from Propofol, Alfentanil and Nitrous Oxide Anesthesia.
Pierce, E.T., Drover, D., Plourde, G., Loyd, G., Eugene, O. Anesthesiology 2001; 95:A283.
 
Quantitative EEG Changes Associated With Loss And Return Of Consciousness In Healthy Adult Volunteers Anaesthetized With Propofol Or Sevoflurane.
Gugino L.D., Chabot R.J., Prichep L.S., John E.R., Formanek V., Aglio L.S. Br J Anaesth. 2001 Sep;87(3):421-8.
 
Invariant Reversible QEEG Effects of Anesthetics.
John E.R., Prichep L.S., Kox W., Valdés-Sosa P., Bosch-Bayard J., Aubert E., Tom M., di Michele F., Gugino L.D. Conscious Cogn. 2001 Jun;10(2):165-83.
 

* Duplicate abstracts or publications are excluded

indicates an abstract presented at a congress

indicates peer-reviewed journal article

indicates an Open Access article