Clinical Evidence

Masimo is passionate about making innovative technologies that give clinicians the tools they need to do what is best for patient care. That's why it is gratifying to see so many independent clinicians and clinical researchers take the time to independently evaluate our products and technologies.

Click on the links below to read the featured studies from all of Masimo’s technologies, or in the sections below for access by subject area to all studies.*

Featured Clinical Studies

Masimo SET® Pulse Oximetry

Temporal quantification of oxygen saturation ranges: an effort to reduce hyperoxia in the neonatal intensive care unit
M J Bizzarro, F Y Li, K Katz, V Shabanova, R A Ehrenkranz and V Bhandari. Journal of Perinatology (2014) 34, 33–38; doi:10.1038/jp.2013.122; published online 26, September 2013
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Pulse oximetry with clinical assessment to screen for congenital heart disease in neonates in China: a prospective study.
Zhao Q., Ma X., Ge X, Liu F. , YanW., Wu L., Ye M., Liang X., Zhang J., Gao Y., Jia B., Huang G., The Neonatal Congenital Heart Disease Screening Group. The Lancet, Available online 22 April 2014.
Performance of Three New-Generation Pulse Oximeters during Motion and Low Perfusion in Volunteers.
Shah N, Ragaswamy HB, Govindugari K, Estanol L. J Clin Anesth. 2012 Aug;24(5):385-91.
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Prevention of Retinopathy of Prematurity in Preterm Infants through Changes in Clinical Practice and SpO2 Technology.
Castillo A., Deulofeut R., Critz A., Sola A. Acta Paediatr. 2011 Feb;100(2):188-92.
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Impact of pulse oximetry screening on the detection of duct dependent congenital heart disease: a Swedish prospective screening study in 39,821 newborns.
de-Wahl Granelli A., Wennergren M., Sandberg K., Mellander M., Bejlum C., Inganäs L., Eriksson M., Segerdahl N., Agren A., Ekman-Joelsson B.M., Sunnegårdh J., Verdicchio M., Östman-Smith I. BMJ. 2009;Jan 8;338.
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More Reliable Oximetry Reduces the Frequency of Arterial Blood Gas Analyses and Hastens Oxygen Weaning after Cardiac Surgery: A Prospective, Randomized Trial of the Clinical Impact of a New Technology.
Durbin C.G. Jr., Rostow S.K. Crit Care Med. 2002 Aug;30(8):1735-40.
Reliability of Conventional and New Pulse Oximetry in Neonatal Patients.
Hay W.W., Rodden D.J., Collins S.M., Melara D.L., Hale K.A., Fashaw L.M. J Perinatol. 2002 Jul-Aug;22(5):360-6.
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"Motion-Resistant" Pulse Oximetry: A Comparison of New and Old Models.
Barker S.J. Anesth Analg. 2002 Oct;95(4):967-72.
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Pleth Variability Index (PVI®)

Pleth Variability Index-Directed Fluid Management in Abdominal Surgery under Combined General and Epidural Anesthesia
Yu Y., Dong J., Xu Z., Shen H., Zheng J. J Clin Monit Comput. 2014 Feb 21.
Goal-Directed Fluid Management Based on the Pulse Oximeter-Derived Pleth Variability Index Reduces Lactate Levels and Improves Fluid Management.
Forget P, Lois F, de Kock M. Anesth Analg. 2010 Oct;111(4):910-4.
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Pleth Variability Index to Monitor the Respiratory Variations in the Pulse Oximeter Plethysmographic Waveform Amplitude and Predict Fluid Responsiveness in the Operating Theatre.
Cannesson M., Desebbe O., Rosamel P., Delannoy B., Robin J., Bastien O., Lehot J.J. Br J Anaesth. 2008 Aug;101(2):200-6.
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Masimo Patient SafetyNet

Impact of Pulse Oximetry Surveillance on Rescue Events and Intensive Care Unit Transfers: A Before-And-After Concurrence Study.
Taenzer A.H., Pyke J.B., McGrath S.P., Blike G.T. Anesthesiology. 2010 Feb;112(2):282-7.
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Postoperative Monitoring – The Dartmouth Experience.
Taenzer A.H., Blike, G. T. APSF Newsletter 2012.Available at: Accessed June 14, 2012.
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Continuous Pulse Oximetry Monitoring with Clinician Notification is Associated with Lower Patient Mortality in Post-Surgical/Medical Patients
Carlson J. Respiratory Care 2013; 58 (10):1784
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Total Hemoglobin (SpHb®)

Trending and Accuracy of Noninvasive Hemoglobin Monitoring in Pediatric Perioperative Patients
Patino M, Schultz L, Hossain M, Moeller J, Mahmoud M, Gunter J, Kurth CD. Anesth Analg. 2014 Jul 17. [Epub ahead of print] PubMed PMID: 25036374.
Accuracy of a Continuous Noninvasive Hemoglobin Monitor in Intensive Care Unit Patients.
Frasca D., Dahyot-Fizelier C., Catherine K., Levrat Q., Debaene B., Mimoz O. Crit Care Med. 2011 Oct;39(10):2277-82.
The Accuracy of Noninvasive and Continuous Total Hemoglobin Measurement by Pulse CO-Oximetry in Human Subjects Undergoing Hemodilution.
Macknet M.R., Allard M., Applegate R.L., Rook J. Anesth Analg. 2010 Dec;111(6):1424–6.
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Acoustic Respiration Rate (RRa®)

The Accuracy, Precision and Reliability of Measuring Ventilatory Rate and Detecting Ventilatory Pause by Rainbow Acoustic Monitoring and Capnometry.
Ramsay M.A.E., Usman M., Lagow E., Mendoza M., Untalan E., De Vol, E. Anesth Analg 2013
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Accuracy of Respiratory Rate Monitoring using a Non-Invasive Acoustic Method after General Anaesthesia.
Mimoz O., Benard T., Gaucher A., Frasca D., Debaene B. Br J Anaesth. 2012 May;108(5):872-5.
Accuracy of Acoustic Respiration Rate Monitoring in Pediatric Patients
Patino M., Redford D.T., Quigley T.W., Mahmoud M., Kurth C.D., Szmuk P. Paediatr Anaesth. 2013 Sep 3.
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Carboxyhemoglobin (SpCO®)

Accuracy of Noninvasive Multiwave Pulse Oximetry Compared With Carboxyhemoglobin From Blood Gas Analysis in Unselected Emergency Department Patients.
Roth D., Herkner H., Schreiber W., Hubmann N., Gamper G., Laggner A.N., Havel C. Ann Emerg Med. 2011 Jul;58(1):74-9.
Noninvasive Pulse CO-Oximetry Expedites Evaluation and Management of Patients with Carbon Monoxide Poisoning.
Hampson N.B. Am J Emerg Med. 2012 May 23.
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Methemoglobin (SpMet®)

Severe Methemoglobinemia Detected by Pulse Oximetry.
Annabi E.H., Barker S,J. Anesth Analg. 2009;108:898–9.
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SedLine® Brain Function Monitoring

Titration of Delivery and Recovery from Propofol, Alfentanil, and Nitrous Oxide Anesthesia.
Drover D.R., Lemmens H.J., Pierce E.T., Plourde G., Loyd G., Ornstein E., Prichep L.S., Chabot R.J., Gugino L. Anesthesiology 2002; 97:82–9.
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Masimo Capnography and Gas Monitoring

Evaluation of a Transportable Capnometer for Monitoring End-Tidal Carbon Dioxide.
Hildebrandt T., Espelund M., Olsen K.S. Anaesthesia. 2010 Oct;65(10):1017-21.
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* This section is intended to provide access to independent, objective, third-party, and government-sponsored clinical studies and abstracts conducted using Masimo noninvasive technologies, parameters, and products, which are known to Masimo's marketing department. We cannot guarantee that all clinical studies, abstracts, and research are represented. To view the individual clinical studies and abstracts, please click on the appropriate tab.

While clinical studies and abstracts support the effectiveness of Masimo noninvasive technologies and parameters, individual results may vary. Masimo cannot guarantee specific results achieved or suggested in individual studies. Always strictly follow the directions for use (DFU) found in the product manual. Use of Masimo technologies and parameters may not be appropriate for every individual or clinical condition. Understanding the indications and limitations of use can help you make the best decision for your individual situation.

Masimo devices with SpHb, SpCO, and/or SpMet monitoring are not intended to replace laboratory blood testing. Blood samples should be analyzed by laboratory instruments prior to clinical decision making.

ISA AX+ and ISA OR+ are not licensed for sale in Canada.